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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Angiotensinogen</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_Angiotensinogen" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Angiotensinogen
</th></tr>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">452 aa; 49,8 kDa
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Namen</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=333">AGT</a></i>, ANHU, SERPINA8
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<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/106150">106150</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P01019">P01019</a></li>
<li><a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="https://www.informatics.jax.org/marker/MGI:87963">87963</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P01019">Hovergen</a>
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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>
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<td colspan="2" style="text-align:center;"><a href="Euteleostomi" title="Euteleostomi">Euteleostomi</a>
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
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<td style="background:#C3FDB8; color:#202122;">
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Maus
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=183&rn=1">183</a></span>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11606&rn=1">11606</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
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<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000135744;db=core">ENSG00000135744</a></small></small></span>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000031980;db=core">ENSMUSG00000031980</a></small></small></span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P01019">P01019</a>
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<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q3UTR7">Q3UTR7</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000029">NM_000029</a>
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<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007428">NM_007428</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031454">NP_031454</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>
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<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&position=chr1:228904892-228916959">Chr 1: 228.9 – 228.92 Mb</a> </span>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks&position=chr8:124556587-124569707">Chr 8: 124.56 – 124.57 Mb</a> </span>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=183">183</a></span>
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<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=11606">11606</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
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</p><p><b>Angiotensinogen</b> (früher auch <i>Hypertensinogen</i> genannt) ist ein <a href="Protein" title="Protein">Protein</a> und <a href="Prohormon" title="Prohormon">Prohormon</a> mit 452 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>, das durch das <a href="Enzym" title="Enzym">Enzym</a> <a href="Renin" title="Renin">Renin</a> in das aus zehn Aminosäuren bestehende <a href="Peptid" title="Peptid">Peptid</a> <a href="Angiotensin_I" title="Angiotensin I">Angiotensin I</a> umgewandelt wird (sogenannte <a href="Posttranslationale_Modifikation" title="Posttranslationale Modifikation">posttranslationale Modifikation</a>); daraus können weitere <a href="Angiotensine" title="Angiotensine">Angiotensine</a> produziert werden, die jeweils spezifische biologische Funktionen besitzen.
</p>
<div class="mw-heading mw-heading2"><h2 id="Proteinbiosynthese">Proteinbiosynthese</h2></div>
<p>Nach der <a href="Translation_(Biologie)" title="Translation (Biologie)">Translation</a> durch <a href="Hepatozyt" title="Hepatozyt">Hepatozyten</a> und dem Transport zur Leberzellmembran wird die <a href="Signalsequenz" title="Signalsequenz">Signalsequenz</a> von der Proteinkette abgetrennt und das entstehende Angiotensinogen ins Plasma abgegeben. Das in der Leber gebildete Angiotensinogen zirkuliert im menschlichen Blutplasma. Bei der <a href="Serumelektrophorese" title="Serumelektrophorese">elektrophoretischen Auftrennung der Serumeiweiße</a> wandert es in der α<sub>2</sub>-Globulin-Fraktion mit.
</p><p>Die <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a> des humanen Angiotensinogens besteht aus 452 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a> mit einer <a href="Molek%C3%BClmasse" title="Molekülmasse">Molekülmasse</a> von 49.761 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Da</a>.<sup id="cite_ref-u_1-0" class="reference"><a href="#cite_note-u-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Das Gen liegt auf dem langen Arm von <a href="Chromosom_1_(Mensch)" title="Chromosom 1 (Mensch)">Chromosom 1</a>. Daraus wird das Deka<a href="Peptid" title="Peptid">peptid</a> Angiotensin I durch enzymatische Abspaltung der zehn <a href="N-Terminus" title="N-Terminus"><i>N</i>-terminalen</a> Aminosäuren gebildet.
</p><p>Angiotensinogen wurde bei der Maus erstmals 1983 durch Ohkubo <i>et al.</i> und beim Menschen erstmals 1984 durch Kageyama <i>et al.</i> beschrieben.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2></div>
<p>Angiotensinogen ist ein <a href="Pr%C3%A4kursor-Protein" class="mw-redirect" title="Präkursor-Protein">Präkursor-Protein</a> des für die <a href="Blutdruck" title="Blutdruck">Blutdruckregulation</a> wichtigen <a href="Renin-Angiotensin-Aldosteron-System" title="Renin-Angiotensin-Aldosteron-System">Renin-Angiotensin-Aldosteron-Systems</a> (RAAS). Durch enzymatische Spaltung liefert es die <a href="Peptidhormone" class="mw-redirect" title="Peptidhormone">Peptidhormone</a> der Angiotensine. Renin spaltet Angiotensin I ab. <a href="Angiotensin-konvertierendes_Enzym" title="Angiotensin-konvertierendes Enzym">Angiotensin-konvertierendes Enzym</a> (ACE) spaltet Angiotensin II von Angiotensin I ab. Die Angiotensine III und IV können aus I und II entstehen. <a href="Angiotensin-konvertierendes_Enzym_2" title="Angiotensin-konvertierendes Enzym 2">ACE2</a> spaltet Angiotensin II und erzeugt Angiotensin 1-7, das auch mithilfe von <a href="Neprilysin" title="Neprilysin">Neprilysin</a> aus Angiotensin I entstehen kann. ACE2 erzeugt außerdem Angiotensin 1-9 aus Angiotensin I.<sup id="cite_ref-u_1-1" class="reference"><a href="#cite_note-u-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
<pre>Pos. 10 20 30 40 50 480 485 Name
<span style="color:blue;"><—————— <a href="Signalpeptid" class="mw-redirect" title="Signalpeptid">Signalpeptid</a> (1-33) ———————></span><span style="color:brown;"><—————— Angiotensinogen (34-485) —————></span>
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST ... ALHFLGRVAN PLSTA
DRVYIHP FHL Angiotensin I (1-10)
DRVYIHP FH Angiotensin 1-9
DRVYIHP F Angiotensin II (1-8)
ARVYIHP F Angiotensin A
RVYIHP F Angiotensin III (2-8)
VYIHP F Angiotensin IV (3-8)
DRVYIHP Angiotensin 1-7<sup id="cite_ref-u_1-2" class="reference"><a href="#cite_note-u-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</pre>
<div class="mw-heading mw-heading2"><h2 id="Quellen">Quellen</h2></div>
<ol class="references">
<li id="cite_note-u-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-u_1-0">a</a></sup> <sup><a href="#cite_ref-u_1-1">b</a></sup> <sup><a href="#cite_ref-u_1-2">c</a></sup></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P01019">P01019</a></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Ohkubo, H. <i>et al.</i> (1983): <i>Cloning and sequence analysis of cDNA for rat angiotensinogen.</i> In: <i>Proc. Natl. Acad. Sci. U.S.A.</i> Bd. 80, S. 2196–2200. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/6572971?dopt=Abstract">PMID 6572971</a></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Kageyama, R. <i>et al.</i> (1984): <i>Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence.</i> In: <i>Biochemistry.</i> Bd. 23, S. 3603–3609. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/6089875?dopt=Abstract">PMID 6089875</a></span>
</li>
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